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KMID : 0374019890120040241
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Ewha Medical Journal
1989 Volume.12 No. 4 p.241 ~ p.251
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The Morphologic Study of Vitamin A(Retinol) on 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in the Rats
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Abstract
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Induction of intestinal tumor by subcutaneous injection of 1, 2-dimethylhydrazine(DMH), 20 mg/kg/week, during 20 weeks was studied in rats fed by vitamin A(retinol) 50g, 500g/day.
Mucosal epithelial cell hyperplasia and mitosis in one crypt was not significantly inhibited by vitamin A administration(P>0.05),In electron microscopic findings, the cytoplasmic vacuoles were decreased in DMH+vitamin A-treated rats than DMH only. Dysplasia of the colonic mucosa in DMH+vitamin A-treated group were more slowly developed than DMH-treated rats. In DMH-treated rats the tumors were early detected after 14 weeks, but in DMH+vitamin A-treated groups were seen after 20 weeks.
All these findings suggest that vitamin A can effectively prevent cytotoxicity of carcinogen in early phase, but can not prevent carcinogenesis in late phase.
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KEYWORD
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